SOLID SMEDDS THESIS

At this point, amount of water, oil, surfactant and cosurfactant added was noted. Visual observations were made immediately after dilution for self-microemulsification efficiency and transparency. Formulation and development Saturation solubility study Sr. Phase behavior and microstructure. Self-emulsification ability of surfactants was assessed to select the best surfactant from large pool of surfactants. Received May 19; Accepted Sep

It has been shown that finely divided solid particles can be used as emulsifying agents and emulsion stabilizer. Resulting mixtures were evaluated visually for transparency and flow properties; and by polarizing microscope for optical isotropy. In this study, we intended to prepare and characterize solid self-nanoemulsifying drug delivery system for oral delivery of loratadin as the model insoluble drug. Therefore, immunosuppressive activity of FK would be clinically evident by reduction in T and B cell lymphocytes in peripheral blood and can be used as pharmacodynamic marker for FK 1 , 3. Ratio of oil to surfactant was decided on the basis of requirements stated by Pouton 13 for spontaneously emulsifying systems and represents Type III system. Open in a separate window. Because of hydrophobic nature of FK , it may affect globule size of microemulsions or may precipitate upon dilution.

Oral bioavailability of silymarin phytocomplex formulated as self-emulsifying pellets. Published online Dec The composition of SNE pellets is shown in Table 2.

Furthermore, SMEDDS offer various advantages such as reduction in inter- and intra subject pharmacokinetic variability, improvement in lymphatic transport and GI permeability and reversal of P-gp efflux, all of which help in improving bioavailability of hydrophobic drugs 11 — Oil and surfactant were accurately weighed in to glass vial. Stabilisation of emulsion droplets by fine powders. Improved absorption can be achieved by use of delivery systems, which can enhance drug dissolution from its dosage form and maintains drug in dissolved state in GI fluids.

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The summary of friability test results is shown in Table 3. Secondly the result could be related to the role of fine solid components of pellet formulations as an auxiliary emulsifying agent. Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone. Study of Reconstitution properties of the spray dried powders Development of sustained release bilayer matrix tablet using different polymers.

In Vivo Efficacy Studies: Friability test The summary of friability test results is shown in Table 3. Phase behavior and microstructure. D thesis of Ms.

The regression analysis did not show any significant relevancy smesds aspect ratio and studied formulation factors; while it is indicated that the sphericity could be affected by the factors. At this point, amount of water, oil, surfactant and cosurfactant added was noted.

Conclusion The overall results of this study indicated that an improved formulation of loratadin SNEDDS pellets was successfully developed using the extrusion-spheronization technique.

solid smedds thesis

Additionally, FK shows large intra- and inter-individual pharmacokinetic variability 3. Then, the adsorbed mixture was blended with other components MCC, lactose and crosscarmelose for 5 minutes.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Lauroglycol 90 and Capryol 90 are propylene glycol mono- and diester of lauric acid and caprylic acid, respectively. Physical integrity of microemulsion formed and drug solublization capacity after dilution of SMEDDS must be assessed and ensured as it gives an idea about its performance in vivo 22 As we found out in this test and according to a previous study, adding the lactose had less effect on disintegration time, but would be useful to improve appearance of the pellets.

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solid smedds thesis

Ratio of oil to surfactant was decided on the basis of requirements stated by Pouton 13 for spontaneously emulsifying systems and represents Type III system.

Mean globule size and polydispersity index P. Carbitol and propylene glycol, hydrophilic cosurfactants increased spontaneity of microemulsion formation. Cremophor EL and Tween 20 rendered effective microemulsification and were selected for further study. Received May 19; Accepted Sep DisouzaPrincipalTatyasaheb kore college of Pharmacy, Warananagar.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Physical properties of Drug The M. In splid to view it, please contact the author of the presentation. Clinical pharmacokinetics and thesls of FK in solid organ transplantation. You do not have the permission to view this presentation. Medha Joshi, Sulabha Pathak.

Quality assessment of the produced pellets was made by evaluating their size and shape, 22 and percentages of the SE pellets in the sieve fraction are shown in Table 3. Microemulsion formulation for enhanced absorption of poorly soluble drugs I. Microemulsion-based media as novel drug delivery systems.